Karakalpakstan was an Auutonomous Soviet Socialist Republic. When the USSR broke down, it briefly declared independence, before becommming an automous region of Uzbekistan on the condition it retain its autonomy. Karakalpakstan's population is approximately 5% of Uzbekistan's total population, but spans about 40% of it's territory. The population speaks a language related to but distinct from Uzbek. Karakalpakstan has it's own parliament (the Jokargi Kenes) and constitution, but the Uzbek government still retains final power.
Recently, the Uzbekistan government attempted to pass constitutional amendments that would have stripped Karakalpakstan of it's constitutionally ingrained right to self-determination, with resulted in riots and demonstrations.